CLIC1
Protein-coding gene in the species Homo sapiens
CLIC1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K0M , 1K0N , 1K0O , 1RK4 , 3O3T , 3P8W , 3P90 , 3QR6 , 3SWL , 3TGZ , 3UVH , 4IQA , 4JZQ , 4K0G , 4K0N
Identifiers Aliases CLIC1 External IDs OMIM : 602872 ; MGI : 2148924 ; HomoloGene : 20343 ; GeneCards : CLIC1 ; OMA :CLIC1 - orthologs Wikidata
Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene .[ 5] [ 6]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH , and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[ 6]
Interactions
CLIC1 has been shown to interact with TRAPPC2 .[ 7]
See also
References
^ a b c ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 GRCh38: Ensembl release 89: ENSG00000213719, ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007041 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei" . J Biol Chem . 272 (19): 12575–82. doi :10.1074/jbc.272.19.12575 PMID 9139710 . ^ a b "Entrez Gene: CLIC1 chloride intracellular channel 1" .^ Fan L, Yu Wei, Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins" . FEBS Lett . 540 (1–3). Netherlands: 77–80. Bibcode :2003FEBSL.540...77F . doi :10.1016/S0014-5793(03)00228-X ISSN 0014-5793 . PMID 12681486 . S2CID 8573651 .
Further reading
Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters . 584 (10): 2112–21. Bibcode :2010FEBSL.584.2112S . doi :10.1016/j.febslet.2010.03.013 . PMID 20226783 . S2CID 21056278 . Okubo K, Hori N, Matoba R, et al. (1994). "Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression". Nat. Genet . 2 (3): 173–9. doi :10.1038/ng1192-173 . PMID 1345164 . S2CID 35309579 . Frigerio JM, Berthézène P, Garrido P, et al. (1995). "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing". Hum. Mol. Genet . 4 (1): 37–43. doi :10.1093/hmg/4.1.37 . PMID 7711732 . Singh H, Ashley RH (2006). "Redox Regulation of CLIC1 by Cysteine Residues Associated with the Putative Channel Pore" . Biophys. J . 90 (5): 1628–1638. Bibcode :2006BpJ....90.1628S . doi :10.1529/biophysj.105.072678 . PMC 1367314 PMID 16339885 . Liew CC, Hwang DM, Fung YW, et al. (1994). "A catalogue of genes in the cardiovascular system as identified by expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 91 (22): 10645–9. Bibcode :1994PNAS...9110645L . doi :10.1073/pnas.91.22.10645 PMC 45078 PMID 7938007 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Heiss NS, Poustka A (1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics . 45 (1): 224–8. doi :10.1006/geno.1997.4922 . PMID 9339381 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Tulk BM, Edwards JC (1998). "NCC27, a homolog of intracellular Cl− channel p64, is expressed in brush border of renal proximal tubule" . Am. J. Physiol . 274 (6 Pt 2): F1140–9. doi :10.1152/ajprenal.1998.274.6.F1140 PMID 9841507 . S2CID 39652235 . Chuang JZ, Milner TA, Zhu M, Sung CH (1999). "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons" . J. Neurosci . 19 (8): 2919–28. doi :10.1523/JNEUROSCI.19-08-02919.1999 PMC 6782274 PMID 10191309 . Ribas G, Neville M, Wixon JL, et al. (1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J. Immunol . 163 (1): 278–87. doi :10.4049/jimmunol.163.1.278 . PMID 10384126 . Berryman M, Bretscher A (2000). "Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli" . Mol. Biol. Cell . 11 (5): 1509–21. doi :10.1091/mbc.11.5.1509 . PMC 14863 PMID 10793131 . Tonini R, Ferroni A, Valenzuela SM, et al. (2000). "Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells" . FASEB J . 14 (9): 1171–8. doi :10.1096/fasebj.14.9.1171 PMID 10834939 . S2CID 30652670 . Valenzuela SM, Mazzanti M, Tonini R, et al. (2001). "The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle" . J. Physiol . 529 (3): 541–52. doi :10.1111/j.1469-7793.2000.00541.x . PMC 2270212 PMID 11195932 . Harrop SJ, DeMaere MZ, Fairlie WD, et al. (2002). "Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution" . J. Biol. Chem . 276 (48): 44993–5000. doi :10.1074/jbc.M107804200 PMID 11551966 . Warton K, Tonini R, Fairlie WD, et al. (2002). "Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1" . J. Biol. Chem . 277 (29): 26003–11. doi :10.1074/jbc.M203666200 PMID 11978800 . Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member" . J. Biol. Chem . 277 (43): 40973–80. doi :10.1074/jbc.M112277200 PMID 12163479 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins" . FEBS Lett . 540 (1–3): 77–80. Bibcode :2003FEBSL.540...77F . doi :10.1016/S0014-5793(03)00228-X PMID 12681486 . S2CID 8573651 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Littler DR, Harrop SJ, Fairlie WD, et al. (2004). "The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition" . J. Biol. Chem . 279 (10): 9298–305. doi :10.1074/jbc.M308444200 PMID 14613939 . Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin". FEBS J . 274 (24): 6306–6316. doi :10.1111/j.1742-4658.2007.06145.x . PMID 18028448 . S2CID 22494250 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
PDB gallery
1k0m : Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms
1k0n : Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione
1k0o : Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel
1rk4 : Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1
