KCNG1

KCNG1
Identifiers
Aliases	KCNG1, K13, KCNG, KV6.1, kH2, potassium voltage-gated channel modifier subfamily G member 1
External IDs	OMIM: 603788; MGI: 3616086; HomoloGene: 20515; GeneCards: KCNG1; OMA:KCNG1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	51,023,107 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	168,123,656 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; ventricular zone; ; left uterine tube; ; ganglionic eminence; ; stromal cell of endometrium; ; buccal mucosa cell; ; tail of epididymis; ; myometrium; ; entorhinal cortex; ; seminal vesicula;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; subiculum; ; hippocampus proper; ; superior frontal gyrus; ; facial motor nucleus; ; temporal lobe; ; amygdala; ; visual cortex; ; primary visual cortex; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated potassium channel activity; ion channel activity; potassium channel activity; delayed rectifier potassium channel activity; voltage-gated ion channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; regulation of delayed rectifier potassium channel activity; protein homooligomerization; ion transport; transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3755
	241794
	ENSG00000026559
	ENSMUSG00000074575
	Q9UIX4
	A2BDX4
	NM_002237; NM_172318
	NM_001081134; NM_001379458
	NP_002228
	NP_001074603; NP_001366387
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily G member 1 is a protein that in humans is encoded by the KCNG1 gene.^[5]^[6]^[7]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Alternative splicing results in at least two transcript variants encoding distinct isoforms.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000026559 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074575 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y (Feb 1998). "Isolation, characterization, and mapping of two human potassium channels". Biochem Biophys Res Commun. 241 (3): 675–81. doi:10.1006/bbrc.1997.7830. PMID 9434767.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b "Entrez Gene: KCNG1 potassium voltage-gated channel, subfamily G, member 1".

External links

Kv6.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNG1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000026559 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074575 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9434767-5] Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y (Feb 1998). "Isolation, characterization, and mapping of two human potassium channels". Biochem Biophys Res Commun. 241 (3): 675–81. doi:10.1006/bbrc.1997.7830. PMID 9434767.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-7] "Entrez Gene: KCNG1 potassium voltage-gated channel, subfamily G, member 1".

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KCNG1

See also

References

Further reading

External links