KCNK3

KCNK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	6RV2, 6RV3, 6RV4
Identifiers
Aliases	KCNK3, K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, potassium two pore domain channel subfamily K member 3, TASK1
External IDs	OMIM: 603220; MGI: 1100509; HomoloGene: 1692; GeneCards: KCNK3; OMA:KCNK3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	26,733,420 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	30,782,615 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; adrenal cortex; ; left adrenal cortex; ; right adrenal cortex; ; beta cell; ; lower lobe of lung; ; right lung; ; paraflocculus of cerebellum; ; pons; ; upper lobe of lung;
	Top expressed in
	adrenal gland; ; lobe of prostate; ; brown adipose tissue; ; myocardium of ventricle; ; right ventricle; ; cerebellar cortex; ; facial motor nucleus; ; lobe of cerebellum; ; cardiac muscles; ; tunica adventitia of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	S100 protein binding; potassium channel activity; protein homodimerization activity; open rectifier potassium channel activity; potassium ion leak channel activity; ion channel activity; protein heterodimerization activity; growth factor activity; protein C-terminus binding; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular space;
Biological process	cochlea development; ion transport; cellular response to zinc ion; potassium ion transport; ion transmembrane transport; brain development; cardiac conduction; potassium ion transmembrane transport; cellular response to hypoxia; negative regulation of cytosolic calcium ion concentration; chemical synaptic transmission; stabilization of membrane potential; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	3777
	16527
	ENSG00000171303
	ENSMUSG00000049265
	O14649
	O35111
	NM_002246
	NM_010608
	NP_002237
	NP_034738
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.^[5]^[6]^[7]^[8]

This gene encodes K_2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

KCNK3 has been shown to interact with YWHAB^[9] and S100A10.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171303 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049265 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M (Dec 1997). "TASK, a human background K+ channel to sense external pH variations near physiological pH". EMBO J. 16 (17): 5464–71. doi:10.1093/emboj/16.17.5464. PMC 1170177. PMID 9312005.
^ Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID 9721223.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK3 potassium channel, subfamily K, member 3".
^ O'Kelly, Ita; Butler Margaret H; Zilberberg Noam; Goldstein Steve A N (Nov 2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4). United States: 577–88. doi:10.1016/S0092-8674(02)01040-1. ISSN 0092-8674. PMID 12437930. S2CID 15898814.
^ Girard, Christophe; Tinel Norbert; Terrenoire Cécile; Romey Georges; Lazdunski Michel; Borsotto Marc (Sep 2002). "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1". EMBO J. 21 (17). England: 4439–48. doi:10.1093/emboj/cdf469. ISSN 0261-4189. PMC 125412. PMID 12198146.

External links

KCNK3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[WikiPathways-9] The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171303 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049265 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9312005-5] Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M (Dec 1997). "TASK, a human background K+ channel to sense external pH variations near physiological pH". EMBO J. 16 (17): 5464–71. doi:10.1093/emboj/16.17.5464. PMC 1170177. PMID 9312005.

[pmid9721223-6] Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID 9721223.

[pmid16382106-7] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-8] "Entrez Gene: KCNK3 potassium channel, subfamily K, member 3".

[pmid12437930-10] O'Kelly, Ita; Butler Margaret H; Zilberberg Noam; Goldstein Steve A N (Nov 2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4). United States: 577–88. doi:10.1016/S0092-8674(02)01040-1. ISSN 0092-8674. PMID 12437930. S2CID 15898814.

[pmid12198146-11] Girard, Christophe; Tinel Norbert; Terrenoire Cécile; Romey Georges; Lazdunski Michel; Borsotto Marc (Sep 2002). "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1". EMBO J. 21 (17). England: 4439–48. doi:10.1093/emboj/cdf469. ISSN 0261-4189. PMC 125412. PMID 12198146.

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[§ 1]

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KCNK3

Interactive pathway map

Interactions

See also

References

Further reading

External links