GPRC6A

GPRC6A
Identifiers
Aliases	GPRC6A, GPCR, bA86F4.3, G protein-coupled receptor class C group 6 member A
External IDs	OMIM: 613572; MGI: 2429498; HomoloGene: 17529; GeneCards: GPRC6A; OMA:GPRC6A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	116,829,083 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	51,507,557 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; salivary gland; ; minor salivary glands; ; islet of Langerhans; ; human kidney; ; right adrenal gland; ; right adrenal cortex; ; muscle of thigh; ; left adrenal gland;
	Top expressed in
	embryo; ; embryo; ; left lung lobe; ; right lung lobe; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; signaling receptor activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; intracellular anatomical structure; membrane; integral component of plasma membrane;
Biological process	response to amino acid; calcium-mediated signaling; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	222545
	210198
	ENSG00000173612
	ENSMUSG00000019905
	Q5T6X5
	Q8K4Z6
	NM_148963; NM_001286354; NM_001286355
	NM_153071
	NP_001273283; NP_001273284; NP_683766
	NP_694711
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene.^[5] This protein functions as a receptor of L-α-amino acids,^[6] cations (e.g., calcium),^[7] osteocalcin,^[8] and steroids.^[9] It is a membrane androgen receptor.

Clinical significance

GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173612 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019905 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".
^ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. S2CID 469049.
^ Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.
^ Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.
^ Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496.
^ Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate. 72 (4): 399–409. doi:10.1002/pros.21442. PMC 3183291. PMID 21681779.

External links

GPRC6A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
"Calcium-Sensing Receptors: GPRC₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173612 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019905 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".

[pmid15576628-6] Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. S2CID 469049.

[pmid16199532-7] Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.

[pmid21425331-8] Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.

[pmid20947496-9] Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496.

[pmid21681779-10] Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate. 72 (4): 399–409. doi:10.1002/pros.21442. PMC 3183291. PMID 21681779.

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GPRC6A

Clinical significance

See also

References

Further reading

External links