Kaliotoxin 1

Kaliotoxin 1, KTx 1

Potassium channel toxin alpha-KTx 3.1
Andere Namen

Kaliotoxin 1, KTx 1

Vorhandene Strukturdaten: PDB 1KTX, PDB 1XSW, PDB 2KTX

Masse/Länge Primärstruktur 38 Aminosäuren, 4.156 Da
Bezeichner
Externe IDs

Kaliotoxin 1 (synonym Kaliumkanaltoxin alpha-KTx 3.5) ist ein Toxin aus dem Skorpion Androctonus australis.

Eigenschaften

Kaliotoxin 1 ist ein Protein und Skorpiontoxin aus A. australis, wie auch Kaliotoxin 2. Es bindet und hemmt spannungsgesteuerte Kaliumkanäle vom Typ Kv1.3[1] (Kd = 0,65 nM), Kv1.6.[2] und Kv1.1/KCNA1 (Kd = 41 nM) sowie KCa1.1/KCNMA1 (Ki = 1560 nM), nicht aber Kv1.2/KCNA2, Kv1.5/KCNA5 und Kv3.1/KCNC1. Kaliotoxin 1 und 2 sind strukturell am nächsten mit Agitoxin 1, Agitoxin 2 und Agitoxin 3 verwandt.[3]

Einzelnachweise

  1. ↑ A. Lange, K. Giller, S. Hornig, M. F. Martin-Eauclaire, O. Pongs, S. Becker, M. Baldus: Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR. In: Nature. Band 440, Nummer 7086, April 2006, S. 959–962, doi:10.1038/nature04649, PMID 16612389.
  2. ↑ O. V. Nekrasova, A. D. Volyntseva, K. S. Kudryashova, V. N. Novoseletsky, E. A. Lyapina, A. V. Illarionova, S. A. Yakimov, Y. V. Korolkova, K. V. Shaitan, M. P. Kirpichnikov, A. V. Feofanov: Complexes of Peptide Blockers with Kv1.6 Pore Domain: Molecular Modeling and Studies with KcsA-Kv1.6 Channel. In: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Band 12, Nummer 2, Juni 2017, S. 260–276, doi:10.1007/s11481-016-9710-9, PMID 27640211.
  3. ↑ Hervé Rochat: Animal Toxins. Springer Science & Business Media, 2000, ISBN 978-3-764-35983-6, S. 184.

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