ARID3A

ARID3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KK0, 4LJX
Identifiers
Aliases	ARID3A, BRIGHT, DRIL1, DRIL3, E2FBP1, AT-rich interaction domain 3A
External IDs	OMIM: 603265; MGI: 1328360; HomoloGene: 124247; GeneCards: ARID3A; OMA:ARID3A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	975,939 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,790,852 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; placenta; ; bone marrow cells; ; left testis; ; right testis; ; stromal cell of endometrium; ; buccal mucosa cell; ; granulocyte; ; sural nerve;
	Top expressed in
	ovarian follicle; ; granulocyte; ; tibiofemoral joint; ; tail of embryo; ; yolk sac; ; germinal epithelium; ; gastrula; ; genital tubercle; ; ovarian follicle; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; DNA binding; protein binding; chromatin binding; DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	membrane raft; nucleus; nucleoplasm; cytoplasm; cytosol; intracellular membrane-bounded organelle;
Biological process	positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	1820
	13496
	ENSG00000116017
	ENSMUSG00000019564
	Q99856
	Q62431
	NM_005224
	NM_001288625; NM_001288626; NM_007880
	NP_005215
	NP_001275554; NP_001275555; NP_031906
	Wikidata
View/Edit Human	View/Edit Mouse

AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ARID3A gene.^[5]^[6]

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.^[6]

Interactions

ARID3A has been shown to interact with:

BTK,^[7] and
E2F1^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116017 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019564 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kortschak RD, Reimann H, Zimmer M, Eyre HJ, Saint R, Jenne DE (Jul 1998). "The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome". Genomics. 51 (2): 288–92. doi:10.1006/geno.1998.5259. PMID 9722953.
^ ^a ^b "Entrez Gene: ARID3A AT rich interactive domain 3A (BRIGHT-like)".
^ Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF (Mar 2004). "The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations". Cellular Immunology. 228 (1): 42–53. doi:10.1016/j.cellimm.2004.03.004. PMID 15203319.
^ Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K (Aug 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene. 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID 9780002. S2CID 23588950.