CP-154,526

CP-154,526
	N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[3,2-e]pyrimidin-4-amine
Identifikacija
CAS registarski broj	157286-86-7
PubChem	5311055
Jmol-3D slike	Slika 1
SMILES
	CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C
InChI
	InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 ; Kod: FHQYJZCJRZHINA-UHFFFAOYSA-N
Svojstva
Molekulska formula	C23H32N4
Molarna masa	364.53 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

CP-154,526 je potentan i selektivan antagonist Kortikotropin-oslobađajućeg hormonskog receptor 1 koji je razvila kompanija Pfizer.^[3]

CP-154,526 se ispituje za moguću upotrebu u lečenju alkoholizma.^[4]^[5]

Povezano

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD 3rd, Winston EN, Chen YL, Heym J (September 1996). „CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors”. Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10477–82. DOI:10.1073/pnas.93.19.10477. PMC 38410. PMID 8816826. ^{[mrtav link]}
↑ „Drug Has Potential To Prevent Alcoholics From Relapsing”. Science News. ScienceDaily. 2. 8. 2008.. Pristupljeno 9. 8. 2008.
↑ Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ (July 2008). „Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism”. Proc. Natl. Acad. Sci. U.S.A. 105 (26): 9070–5. DOI:10.1073/pnas.0710181105. PMC 2449366. PMID 18591672.

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