Himerin 1

Himerin 1
	Kristalna struktura ljudskog himerina 1 (CHN1)
Identifikatori
Simbol	CHN1
Alt. simboli	CHN
Entrez	1123
Hugo	1943
OMIM	118423
RefSek	NM_001822
UniProt	P15882
Drugi podaci
Lokus	Hrom. 2 q31-q32.1

Himerin 1, (CHN1) takođe poznat kao alfa-1-himerin, n-himerin je protein koji je kod ljudi kodiran CHN1 genom.^[2]^[3]

Himerin 1 je aktivirajući protein GTPaze koji je specifičan za RAC GTP-vezujuće proteine. On je prvenstveno izražen u mozgu i smatra se da učestvuje u prenosu signala.

Ovaj gen kodira aktivirajući protein GTPaze za p21-rac i forbolni estarski receptor. On učestvuje u procesu nalaženja puta okularnhih motornih aksona.

Reference

↑ „RCSB Protein Data Bank - Structure Summary for 3CXL - Crystal structure of human chimerin 1 (CHN1)”.
↑ Hall C, Monfries C, Smith P, Lim HH, Kozma R, Ahmed S, Vanniasingham V, Leung T, Lim L (January 1990). „Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene”. J. Mol. Biol. 211 (1): 11–6. DOI:10.1016/0022-2836(90)90006-8. PMID 2299665.
↑ Qi RZ, Ching YP, Kung HF, Wang JH (March 2004). „Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain”. FEBS Lett. 561 (1–3): 177–80. DOI:10.1016/S0014-5793(04)00174-7. PMID 15013773.

Vanjske veze

[urlRCSB_Protein_Data_Bank_-_Structure_Summary_for_3CXL_-_Crystal_structure_of_human_chimerin_1_(CHN1)-1] „RCSB Protein Data Bank - Structure Summary for 3CXL - Crystal structure of human chimerin 1 (CHN1)”.

[pmid2299665-2] Hall C, Monfries C, Smith P, Lim HH, Kozma R, Ahmed S, Vanniasingham V, Leung T, Lim L (January 1990). „Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene”. J. Mol. Biol. 211 (1): 11–6. DOI:10.1016/0022-2836(90)90006-8. PMID 2299665.

[pmid15013773-3] Qi RZ, Ching YP, Kung HF, Wang JH (March 2004). „Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain”. FEBS Lett. 561 (1–3): 177–80. DOI:10.1016/S0014-5793(04)00174-7. PMID 15013773.

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