Himerin 2

Himerin 2
	; PDB prikaz baziran na 1xa6.
Dostupne strukture
	1XA6
Identifikatori
Simboli	CHN2; ARHGAP3; BCH; CHN2-3; RHOGAP3
Vanjski ID	OMIM: 602857 MGI: 1917243 HomoloGene: 31213 GeneCards: CHN2 Gene
Ontologija gena
Molekulska funkcija	• SH3/SH2 adapterska aktivnost; • aktivnost GTPaznog aktivatora; • proteinsko vezivanje;
Ćelijska komponenta	• citozol; • membrana;
Biološki proces	• prenos signala posredovan malom GTPazom; • pozitivna regulacija prenosa signala;
Pregled RNK izražavanja
	podaci
Ortolozi

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Beta-himerin je protein koji je kod ljudi kodiran CHN2 genom.^[1]^[2]

Ovaj gen je član himerinske familije i kodira protein s forbol-estar/DAG-tippom zinkovog prsta, Rho-GAP domenom i SH2 domenom. Ovaj protein ima GTPazno aktivirajuće proteinsko dejstvo koje je regulisano vezivanjem fosfolipida. Vezivanje diacilglicerola (DAG) indukuje translokaciju proteina iz citozola u membranu Goldžijevog aparata.

Reference

↑ Leung T, How BE, Manser E, Lim L (Jun 1994). „Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain”. J Biol Chem 269 (17): 12888–92. PMID 8175705.
↑ „Entrez Gene: CHN2 chimerin (chimaerin) 2”.

Literatura

Yuan S, Miller DW, Barnett GH, et al. (1995). „Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma”. Cancer Res. 55 (15): 3456–61. PMID 7614486.
Caloca MJ, Fernandez N, Lewin NE, et al. (1997). „Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters”. J. Biol. Chem. 272 (42): 26488–96. DOI:10.1074/jbc.272.42.26488. PMID 9334226.
Caloca MJ, Garcia-Bermejo ML, Blumberg PM, et al. (1999). „beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain”. Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11854–9. DOI:10.1073/pnas.96.21.11854. PMC 18376. PMID 10518540.
Caloca MJ, Wang H, Delemos A, et al. (2001). „Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor”. J. Biol. Chem. 276 (21): 18303–12. DOI:10.1074/jbc.M011368200. PMID 11278894.
Wang H, Kazanietz MG (2002). „Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain”. J. Biol. Chem. 277 (6): 4541–50. DOI:10.1074/jbc.M107150200. PMID 11689559.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Nishiu M, Yanagawa R, Nakatsuka S, et al. (2003). „Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression”. Jpn. J. Cancer Res. 93 (8): 894–901. DOI:10.1111/j.1349-7006.2002.tb01335.x. PMID 12716467.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
Caloca MJ, Wang H, Kazanietz MG (2004). „Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor”. Biochem. J. 375 (Pt 2): 313–21. DOI:10.1042/BJ20030727. PMC 1223697. PMID 12877655.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Canagarajah B, Leskow FC, Ho JY, et al. (2004). „Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin”. Cell 119 (3): 407–18. DOI:10.1016/j.cell.2004.10.012. PMID 15507211.
Hashimoto R, Yoshida M, Kunugi H, et al. (2005). „A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men”. Schizophrenia Research 73 (2–3): 383–5. DOI:10.1016/j.schres.2004.01.017. PMID 15653288.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). „High-throughput mapping of a dynamic signaling network in mammalian cells”. Science 307 (5715): 1621–5. DOI:10.1126/science.1105776. PMID 15761153.
Yang C, Liu Y, Leskow FC, et al. (2005). „Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.”. J. Biol. Chem. 280 (26): 24363–70. DOI:10.1074/jbc.M411629200. PMID 15863513.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Siliceo M, García-Bernal D, Carrasco S, et al. (2006). „Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells”. J. Cell. Sci. 119 (Pt 1): 141–52. DOI:10.1242/jcs.02722. PMID 16352660.
Yang C, Liu Y, Lemmon MA, Kazanietz MG (2006). „Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4”. Mol. Cell. Biol. 26 (3): 831–42. DOI:10.1128/MCB.26.3.831-842.2006. PMC 1347034. PMID 16428439.

[pmid8175705-1] Leung T, How BE, Manser E, Lim L (Jun 1994). „Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain”. J Biol Chem 269 (17): 12888–92. PMID 8175705.

[entrez-2] „Entrez Gene: CHN2 chimerin (chimaerin) 2”.

[1]

[2]