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Amidorfin

Amidorfin
Identifikacija
3D model (Jmol)
ChemSpider
  • CC(C)CC(C(=O)N)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)CNC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(Cc2ccc(cc2)O)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCSC)NC(=O)C(Cc3ccccc3)NC(=O)CNC(=O)CNC(=O)C(Cc4ccc(cc4)O)N
Svojstva
C131H200N30O43S2
Molarna masa 2947,29 g/mol
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
Reference infokutije

Amidorfin je endogeni, C-terminalno amidisani, opioidni oktapeptid koji nastaje proteolitičim presecanjem proenkefalina A. Adrenorfin je široko rasprostranjen u mozgu sisara. Posebno visoke koncentracije su nađene u adrenalnoj meduli, posteriornoj hipofizi, i strijatumu.[3][4] U nekim oblastima mozga, amidorfin je intenzivno dalje redukovan u manje fragmente, kao što su ne-opioidni peptid amidorfin-(8—26), kome nedostaje N-terminalna Met-enkefalinska sekvenca amidorfina. Met-enkefalin može takođe da bude proizvod presecanja amidorfina.[5]

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Reference

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди
  2. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  3. ^ BR, Seizinger; Liebisch DC; Gramsch C (1985). „Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla”. Nature. 313 (5997): 57—9. PMID 3965972. 
  4. ^ Liebisch DC, Seizinger BR, Michael G, Herz A (1985). „Novel opioid peptide amidorphin: characterization and distribution of amidorphin-like immunoreactivity in bovine, ovine, and porcine brain, pituitary, and adrenal medulla”. Journal of Neurochemistry. 45 (5): 1495—503. PMID 4045460. 
  5. ^ Liebisch DC, Weber E, Kosicka B, Gramsch C, Herz A, Seizinger BR (1986). „Isolation and structure of a C-terminally amidated nonopioid peptide, amidorphin-(8—26), from bovine striatum: a major product of proenkephalin in brain but not in adrenal medulla”. Proceedings of the National Academy of Sciences of the United States of America. 83 (6): 1936—40. PMC 323199 Слободан приступ. PMID 3456613. 

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