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PB28

PB-28
PB28
Nazivi
IUPAC naziv
1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetra- hydronaphthalen-1-yl)propyl]piperazine
Drugi nazivi
PB28
Identifikacija
3D model (Jmol)
ECHA InfoCard 100.215.826
  • COc1c(CCCC2CCCN3CCN(C4CCCCC4)CC3)c2ccc1
Svojstva
C24H38N2O
Molarna masa 370,57 g/mol
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
ДаY verifikuj (šta je ДаYНеН ?)
Reference infokutije

PB-28[1] je agonist sigma-2 receptora.[2][3][4][5][6]

On je izveden iz cikloheksil-piperazina.

Reference

  1. ^ Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L (1996). „New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives”. J. Med. Chem. 39 (1): 176—82. PMID 8568804. doi:10.1021/jm950409c. 
  2. ^ Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA (2006). „The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells”. Cell Calcium. 40 (1): 23—8. PMID 16687172. doi:10.1016/j.ceca.2006.03.004. 
  3. ^ Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A (2006). „Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer”. Mol. Cancer Ther. 5 (7): 1807—16. PMID 16891467. doi:10.1158/1535-7163.MCT-05-0402. 
  4. ^ Colabufo NA, Berardi F, Abate C, Contino M, Niso M, Perrone R (2006). „Is the sigma2 receptor a histone binding protein?”. Journal of Medicinal Chemistry. 49 (14): 4153—8. PMID 16821775. doi:10.1021/jm0600592. 
  5. ^ Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R (2009). „Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)”. Journal of Medicinal Chemistry. 52 (23): 7817—28. PMID 19842660. doi:10.1021/jm9007505. 
  6. ^ Abate C, Elenewski J, Niso M, Berardi F, Colabufo NA, Azzariti A, Perrone R, Glennon RA (2010). „Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer”. Chemmedchem. 5 (2): 268—73. PMID 20077462. doi:10.1002/cmdc.200900402. 

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