Bromoderma

Bromoderma
Bromoderma
Other names	Bromoderma tuberosum
Specialty	Dermatology

Bromoderma is a skin condition characterized by an eruption of papules and pustules on the skin.^[1]^: 135 It is caused by hypersensitivity to bromides, such as those found in certain drugs. There is at least one reported case of bromoderma caused by excessive consumption of a soft drink (Ruby Red Squirt) containing brominated vegetable oil.^[2]

Signs and symptoms

The disease's symptoms can range from a mild acneiform rash with papules and pustules to more severe conditions like panniculitis, ulcers, and vegetative nodules, also referred to as tuberous or vegetating bromoderma. Lesions usually affect the lower limbs, scalp, and face.^[3]^[4]

Causes

One could characterize bromoderma as a kind of delayed hypersensitivity reaction, even though its pathogenesis is still unknown.^[5] Lesions can develop as soon as eight days after the medicine is first administered, but they typically do so after a prolonged period of use. High sebaceous gland concentrations on the skin are typically the site of lesions.^[6]

Diagnosis

Skin lesions, a patient's history of using bromide, and the healing of lesions following drug withdrawal can all be used to make a diagnosis.^[7]

References

^ James WD, Berger T, Elston D (2006). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Philadelphia: Saunders Elsevier. ISBN 978-0-7216-2921-6.
^ Jih DM, Khanna V, Somach SC (May 2003). "Bromoderma after excessive ingestion of Ruby Red Squirt". The New England Journal of Medicine. 348 (19): 1932–1934. doi:10.1056/NEJM200305083481921. PMID 12736294.
^ Nabatame, Shin; Saito, Yoshiaki; Sakuma, Hiroshi; Komaki, Hirofumi; Nakagawa, Eiji; Sugai, Kenji; Sasaki, Masayuki; Uchiyama, Kentaro; Kosaka, Maki (2010). "Bromoderma in a patient with migrating partial seizures in infancy". Epilepsy Research. 91 (2–3). Elsevier BV: 283–288. doi:10.1016/j.eplepsyres.2010.07.008. ISSN 0920-1211. PMID 20674275. S2CID 3408441.
^ Anzai, Saburo; Fujiwara, Sakuhei; Inuzuka, Miki (2003). "Bromoderma". International Journal of Dermatology. 42 (5). Wiley: 370–371. doi:10.1046/j.1365-4362.2003.01734.x. ISSN 0011-9059. PMID 12755974. S2CID 221812784.
^ Maffeis, Laura; Musolino, Maria Carmela; Cambiaghi, Stefano (2008). "Single-plaque vegetating bromoderma". Journal of the American Academy of Dermatology. 58 (4). Elsevier BV: 682–684. doi:10.1016/j.jaad.2007.08.011. ISSN 0190-9622. PMID 18342716.
^ Hoefel, Isadora da Rosa; Camozzato, Fernanda Oliveira; Hagemann, Laura Netto; Rhoden, Deise Louise Bohn; Kiszewski, Ana Elisa (2016). "Bromoderma in an infant". Anais Brasileiros de Dermatologia. 91 (5 suppl 1). FapUNIFESP (SciELO): 17–19. doi:10.1590/abd1806-4841.20165013. ISSN 0365-0596. PMC 5324981. PMID 28300882.
^ Bel, Susana; Bartralot, Ramón; García, Daniel; Aparicio, Gloria; Castells, Antonio (2001). "Vegetant Bromoderma in an Infant". Pediatric Dermatology. 18 (4). Wiley: 336–338. doi:10.1046/j.1525-1470.2001.01954.x. ISSN 0736-8046. PMID 11576411. S2CID 19631925.