FZD8

Uvojiti receptor 8
	; PDB rendering based on 1ijy.
Dostupne strukture
	1ijy
Identifikatori
Simboli	FZD8; FZ-8; hFZ8
Vanjski ID	OMIM: 606146 MGI: 108460 HomoloGene: 40606 IUPHAR: FZD8 GeneCards: FZD8 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje; • vezivanje PDZ domena;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi

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Uvojiti-8 je protein koji je kod ljudi kodiran FZD8 genom.^[1]^[2]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD8 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Ovaj gen je visoko izražen u dva tipa ćelija ljudskog kancera. Kristalna struktura ekstracelularnog, cisteinom-bogatog domena, srodnog mišjeg proteina je određena.^[2]

Reference

↑ Saitoh T, Hirai M, Katoh M (Apr 2001). „Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2”. Int J Oncol 18 (5): 991–6. PMID 11295046.
↑ ^2,0 ^2,1 „Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)”.

Literatura

Wang Y, Macke JP, Abella BS i dr.. (1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled”. J. Biol. Chem. 271 (8): 4468–4476. DOI:10.1074/jbc.271.8.4468. PMID 8626800.
Finch PW, He X, Kelley MJ i dr.. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Tamai K, Semenov M, Kato Y i dr.. (2000). „LDL-receptor-related proteins in Wnt signal transduction”. Nature 407 (6803): 530–535. DOI:10.1038/35035117. PMID 11029007.
Hartley JL, Temple GF, Brasch MA (2001). „DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788–1795. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863.
Semënov MV, Tamai K, Brott BK i dr.. (2001). „Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6”. Curr. Biol. 11 (12): 951–961. DOI:10.1016/S0960-9822(01)00290-1. PMID 11448771.
Dann CE, Hsieh JC, Rattner A i dr.. (2001). „Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains”. Nature 412 (6842): 86–90. DOI:10.1038/35083601. PMID 11452312.
Yao R, Maeda T, Takada S, Noda T (2001). „Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled”. Biochem. Biophys. Res. Commun. 286 (4): 771–778. DOI:10.1006/bbrc.2001.5430. PMID 11520064.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV i dr.. (2004). „The DNA sequence and comparative analysis of human chromosome 10”. Nature 429 (6990): 375–381. DOI:10.1038/nature02462. PMID 15164054.
Omoto S, Hayashi T, Kitahara K i dr.. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
Lu W, Yamamoto V, Ortega B, Baltimore D (2004). „Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth”. Cell 119 (1): 97–108. DOI:10.1016/j.cell.2004.09.019. PMID 15454084.

Povezano

Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₈”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-09-03.

[pmid11295046-1] Saitoh T, Hirai M, Katoh M (Apr 2001). „Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2”. Int J Oncol 18 (5): 991–6. PMID 11295046.

[entrez-2] 2,0 ^2,1 „Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)”.

[1]

[2]