GPR50

G protein-spregnuti receptor 50
Identifikatori
Simboli	GPR50; H9; MGC125342
Vanjski ID	OMIM: 300207 MGI: 1333877 HomoloGene: 3113 IUPHAR: GPR50 GeneCards: GPR50 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • međućelijska signalizacija;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

GPR50, G protein-spregnuti receptor 50, je protein koji je kod čoveka kodiran GPR50 genom.^[1]^[2]^[3]

Funkcija

GPR50 je član GPCR familije integralnih membranskih proteina. On je sličan melatoninskom receptoru.^[2] GPR50 ima sposobnost formiranja heterodimera sa MT₁ i MT₂ melatoninskim receptorima. Dok GPR50 nema uticaja na MT₂ funkciju, on sprečava MT₁ da veže melatonin i formira kompleks sa G proteinima.^[4]

Klinički značaj

Određeni polimorfizmi GPR50 gena kod žena su povezani sa povišenim rizikom razvoja bipolarnog poremećaja, kliničkom depresijom, i šizofrenijom.^[5] Drugi GPR50 genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućih triglicerida i sniženje nivoa cirkulišućih lipoproteina visoke gustine.^[6]

Literatura

↑ „Entrez Gene: GPR50 G protein-coupled receptor 50”.
↑ ^2,0 ^2,1 Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (May 1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286.
↑ Gubitz AK, Reppert SM (January 1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574.
↑ Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.
↑ Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (May 2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587.
↑ Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (April 2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372.

Dodatna literatura

Reppert SM, Weaver DR, Ebisawa T, et al. (1996). „Cloning of a melatonin-related receptor from human pituitary.”. FEBS Lett. 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286.
Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50).”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Slominski A, Pisarchik A, Zbytek B, et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin.”. J. Cell. Physiol. 196 (1): 144–53. DOI:10.1002/jcp.10287. PMID 12767050.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Thomson PA, Wray NR, Thomson AM, et al. (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.”. Mol. Psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587.
Bhattacharyya S, Luan J, Challis B, et al. (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.”. J. Lipid Res. 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372.
Levoye A, Dam J, Ayoub MA, et al. (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.”. EMBO J. 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.

[entrez-1] „Entrez Gene: GPR50 G protein-coupled receptor 50”.

[pmid8647286-2] 2,0 ^2,1 Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (May 1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286.

[pmid9933574-3] Gubitz AK, Reppert SM (January 1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574.

[pmid16778767-4] Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.

[pmid15452587-5] Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (May 2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587.

[pmid16436372-6] Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (April 2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372.

[1]

[2]

[3]

[4]

[5]

[6]