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Prostaciklinski receptor

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Prostaglandinski I2 (prostaciklinski) receptor (IP1)
Identifikatori
SimboliPTGIR; MGC102830; PRIPR
Vanjski IDOMIM: 600022 MGI: 99535 HomoloGene: 7496 IUPHAR: IP1 GeneCards: PTGIR Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez573919222
EnsemblENSG00000160013ENSMUSG00000043017
UniProtP43119Q3U4F1
RefSeq (mRNA)NM_000960NM_008967
RefSeq (protein)NP_000951NP_032993
Lokacija (UCSC)Chr 19:
51.82 - 51.82 Mb		Chr 7:
16.07 - 16.07 Mb
PubMed pretraga[1][2]

Prostaciklinski receptor (ili prostaglandinski I2 receptor, IP1) je receptor za prostaciklin.

On je član familije G-protein spregnutih receptora. Prostaciklin, glavni proizvod ciklooksigenaze u makrovaskularnom endotelu, uzrokuje potentnu vazodilataciju i inhibiciju agregacije trombocita putem vezivanja za ovaj receptor.[1]

Transdukcija

Prilikom vezivanja za molekul prostaciklina, receptor konformaciju i aktivira Gs, koji aktivira cAMP i povećava aktivnost proteinske kinaze A (PKA).

Reference

  1. ↑ „Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)”. 

Literatura

  • Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166. 
  • Rauvala H, Peng HB (1997). „HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts.”. Prog. Neurobiol. 52 (2): 127–44. DOI:10.1016/S0301-0082(97)00007-5. PMID 9185236. 
  • Smyth EM, FitzGerald GA (2003). „Human prostacyclin receptor.”. Vitam. Horm. 65: 149–65. DOI:10.1016/S0083-6729(02)65063-0. PMID 12481546. 
  • Boie Y, Rushmore TH, Darmon-Goodwin A, et al. (1994). „Cloning and expression of a cDNA for the human prostanoid IP receptor.”. J. Biol. Chem. 269 (16): 12173–8. PMID 7512962. 
  • Katsuyama M, Sugimoto Y, Namba T, et al. (1994). „Cloning and expression of a cDNA for the human prostacyclin receptor.”. FEBS Lett. 344 (1): 74–8. DOI:10.1016/0014-5793(94)00355-6. PMID 7514139. 
  • Ogawa Y, Tanaka I, Inoue M, et al. (1995). „Structural organization and chromosomal assignment of the human prostacyclin receptor gene.”. Genomics 27 (1): 142–8. DOI:10.1006/geno.1995.1016. PMID 7665161. 
  • Duncan AM, Anderson LL, Funk CD, et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Nakagawa O, Tanaka I, Usui T, et al. (1994). „Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.”. Circulation 90 (4): 1643–7. PMID 7923647. 
  • Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548. 
  • Sasaki Y, Takahashi T, Tanaka I, et al. (1997). „Expression of prostacyclin receptor in human megakaryocytes.”. Blood 90 (3): 1039–46. PMID 9242534. 
  • Fisch A, Tobusch K, Veit K, et al. (1997). „Prostacyclin receptor desensitization is a reversible phenomenon in human platelets.”. Circulation 96 (3): 756–60. PMID 9264479. 
  • Smyth EM, Li WH, FitzGerald GA (1998). „Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.”. J. Biol. Chem. 273 (36): 23258–66. DOI:10.1074/jbc.273.36.23258. PMID 9722557. 
  • Kömhoff M, Lesener B, Nakao K, et al. (1999). „Localization of the prostacyclin receptor in human kidney.”. Kidney Int. 54 (6): 1899–908. DOI:10.1046/j.1523-1755.1998.00213.x. PMID 9853255. 
  • Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). „The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.”. J. Biol. Chem. 274 (34): 23707–18. DOI:10.1074/jbc.274.34.23707. PMID 10446129. 
  • Smyth EM, Austin SC, Reilly MP, FitzGerald GA (2000). „Internalization and sequestration of the human prostacyclin receptor.”. J. Biol. Chem. 275 (41): 32037–45. DOI:10.1074/jbc.M003873200. PMID 10889200. 
  • Lawler OA, Miggin SM, Kinsella BT (2001). „Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.”. J. Biol. Chem. 276 (36): 33596–607. DOI:10.1074/jbc.M104434200. PMID 11443126. 
  • Zhang Z, Austin SC, Smyth EM (2001). „Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction.”. Mol. Pharmacol. 60 (3): 480–7. PMID 11502878. 
  • Fortier I, Patry C, Lora M, et al. (2001). „Immunohistochemical localization of the prostacyclin receptor (IP) human bone.”. Prostaglandins Leukot. Essent. Fatty Acids 65 (2): 79–83. DOI:10.1054/plef.2001.0292. PMID 11545623. 

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