GPR18

G protein-spregnuti receptor 18
Identifikatori
Simboli	GPR18;
Vanjski ID	OMIM: 602042 MGI: 107859 HomoloGene: 18814 IUPHAR: GPR18 GeneCards: GPR18 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog;
Celularna komponenta	• membrana; • integralno sa membranom;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

GPR18, N-arahidonil glicinski receptor, je protein koji je kod čoveka kodiran GPR18 genom.^[1]^[2] Zajedno sa drugim „orfanskim“ receptorima GPR55 i GPR119, za GPR18 je utvrđeno da je receptor za endogene lipidne neurotransmitere, nekoliko od kojih se takođe vezuju za kanabinoidne receptore.^[3]^[4]^[5] Nedavna istraživanja daju snažnu podršku hipotezi da GPR18 predstavlja abnormalni kanabidiolni receptor, i sugerišu da N-arahidonoil glicin, endogeni lipidni metabolit anandamida, inicira usmerenu mikroglijalnu migraciju u CNS-u putem GPR18 aktivacije.^[6]

Ligandi

Ligandi za koje je utvrđeno da vezuju GPR18 su:^[6]

Abnormalni kanabidiol
N-arahidonoil glicine

Reference

↑ Gantz I, Muraoka A, Yang YK, Samuelson LC, Zimmerman EM, Cook H, Yamada T (Sep 1997). „Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis”. Genomics 42 (3): 462–6. DOI:10.1006/geno.1997.4752. PMID 9205118.
↑ „Entrez Gene: GPR18 G protein-coupled receptor 18”.
↑ Kohno M, Hasegawa H, Inoue A, Muraoka M, Miyazaki T, Oka K, Yasukawa M (September 2006). „Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18”. Biochemical and Biophysical Research Communications 347 (3): 827–32. DOI:10.1016/j.bbrc.2006.06.175. PMID 16844083.
↑ Burstein S (December 2008). „The elmiric acids: biologically active anandamide analogs”. Neuropharmacology 55 (8): 1259–64. DOI:10.1016/j.neuropharm.2007.11.011. PMC 2621443. PMID 18187165.
↑ Bradshaw HB, Lee SH, McHugh D (September 2009). „Orphan endogenous lipids and orphan GPCRs: a good match”. Prostaglandins & Other Lipid Mediators 89 (3-4): 131–4. DOI:10.1016/j.prostaglandins.2009.04.006. PMC 2740803. PMID 19379823.
↑ ^6,0 ^6,1 McHugh D, Hu SS, Rimmerman N, Juknat A, Vogil Z, Walker JM, Bradshaw HB (March 2010). „N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor”. BMC Neuroscience 11 (1): 44. DOI:10.1186/1471-2202-11-44. PMC 2865488. PMID 20346144.

Literatura

Christian SL, McDonough J, Liu Cy CY, et al. (2002). „An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.”. Genomics 79 (5): 635–56. DOI:10.1006/geno.2002.6765. PMID 11991713.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dunham A, Matthews LH, Burton J, et al. (2004). „The DNA sequence and analysis of human chromosome 13.”. Nature 428 (6982): 522–8. DOI:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kohno M, Hasegawa H, Inoue A, et al. (2006). „Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.”. Biochem. Biophys. Res. Commun. 347 (3): 827–32. DOI:10.1016/j.bbrc.2006.06.175. PMID 16844083.

[pmid9205118-1] Gantz I, Muraoka A, Yang YK, Samuelson LC, Zimmerman EM, Cook H, Yamada T (Sep 1997). „Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis”. Genomics 42 (3): 462–6. DOI:10.1006/geno.1997.4752. PMID 9205118.

[entrez-2] „Entrez Gene: GPR18 G protein-coupled receptor 18”.

[pmid16844083-3] Kohno M, Hasegawa H, Inoue A, Muraoka M, Miyazaki T, Oka K, Yasukawa M (September 2006). „Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18”. Biochemical and Biophysical Research Communications 347 (3): 827–32. DOI:10.1016/j.bbrc.2006.06.175. PMID 16844083.

[pmid18187165-4] Burstein S (December 2008). „The elmiric acids: biologically active anandamide analogs”. Neuropharmacology 55 (8): 1259–64. DOI:10.1016/j.neuropharm.2007.11.011. PMC 2621443. PMID 18187165.

[pmid19379823-5] Bradshaw HB, Lee SH, McHugh D (September 2009). „Orphan endogenous lipids and orphan GPCRs: a good match”. Prostaglandins & Other Lipid Mediators 89 (3-4): 131–4. DOI:10.1016/j.prostaglandins.2009.04.006. PMC 2740803. PMID 19379823.

[pmid20346144-6] 6,0 ^6,1 McHugh D, Hu SS, Rimmerman N, Juknat A, Vogil Z, Walker JM, Bradshaw HB (March 2010). „N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor”. BMC Neuroscience 11 (1): 44. DOI:10.1186/1471-2202-11-44. PMC 2865488. PMID 20346144.

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