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Levomepromazin

Levomepromazin
Klinički podaci
Prodajno imeLevoprome, Neozine, Neurocil, Nosinan
Drugs.comMonografija
Način primeneIntramaskularno, oralno
Farmakokinetički podaci
Poluvreme eliminacije20 h
Identifikatori
CAS broj60-99-1 ДаY
ATC kodN05AA02 (WHO)
PubChemCID 72287
DrugBankDB01403 ДаY
ChemSpider65239 ДаY
KEGGC07192 ДаY
ChEBICHEBI:6838 ДаY
ChEMBLCHEMBL1764 ДаY
Hemijski podaci
FormulaC19H24N2OS
Molarna masa328,472
  • COC1=CC2=C(SC3=C(C=CC=C3)N2C[C@H](C)CN(C)C)C=C1
  • InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1 ДаY
  • Key:VRQVVMDWGGWHTJ-CQSZACIVSA-N ДаY

Levomepromazin je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 328,472 Da.[1][2]. Poznat je i kao metotrimeprazin.

Osobine

Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 0
Broj rotacionih veza 5
Particioni koeficijent[3] (ALogP) 4,5
Rastvorljivost[4] (logS, log(mol/L)) -4,4
Polarna površina[5] (PSA, Å2) 41,0

Reference

  1. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  2. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  3. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  4. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  5. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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