Droperidol

Droperidol
IUPAC ime
	1-{1-[4-(4-fluorofenil)-4-oksobutil]-1,2,5,6-tetrahidropiridin-4-il}-1,3-dihidro-2H-benzimidazol-2-on
Klinički podaci
Kategorija trudnoće	C (SAD);
Način primene	Intravenozno, Intramaskularno
Pravni status
Pravni status	US: ℞-only ;
Farmakokinetički podaci
Metabolizam	Hepatički
Poluvreme eliminacije	2,3 sata
Identifikatori
CAS broj	548-73-2
ATC kod	N05AD08 (WHO)
PubChem	CID 3168
DrugBank	DB00450
UNII	O9U0F09D5X
KEGG	D00308
ChEMBL	CHEMBL1108
Hemijski podaci
Formula	C22H22FN3O2
Molarna masa	379,428 g/mol
	SMILES Fc1ccc(cc1)C(=O)CCCN2CC=C(CC2)N3c4ccccc4NC3=O; ;

Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar [kombinacija sa fentanilom]) je antidopaminergički lek koji se koristi kao antiemetik i antipsihotik.^[1]^[2] Droperidol se takođe koristi za neuroleptanalgezijsku anesteziju i sedaciju pri intenzivnoj nezi.^[3]

Hemija

Droperidol se može sintetisati iz 1-benzil-3-karbetoksipiperidin-4-ona, reakcijom sa o-fenilendiaminom.^[4]^[5]^[6]^[7]

Reference

^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.
^ Schaub I, Lysakowski C, Elia N, Tramèr MR. Low-dose droperidol (≤1 mg or≤15 µg kg-1) for the prevention of postoperative nausea and vomiting in adults: Quantitative systematic review of randomised controlled trials. Eur J Anaesthesiol. 2012;29:286–94
^ C. Janssen, NV Res. Lab., GB 989755 (1962).
^ Janssen, P. A. J.; 1963, Belgian Patent BE 626307 .
^ F.J. Gardocki, J. Janssen, U.S. Patent 3.141.823 (1964).
^ P.A.J. Janssen, U.S. Patent 3.161.645 (1964).

Literatura

Scuderi PE: Droperidol: Many questions, few answers. Anesthesiology 2003; 98: 289-90
Lischke V, Behne M, Doelken P, Schledt U, Probst S, Vettermann J. Droperidol causes a dose-dependent prolongation of the QT interval. Department of Anesthesiology and Resuscitation, Johann Wolfgang Goethe-University Clinics, Frankfurt am Main, Germany.
Emergency Medicine Magazine : https://web.archive.org/web/20110527190715/http://www.emedmag.com/html/pre/tri/1005.asp